A wave of venture investment into new manufacturing startups looks set to transform American manufacturing.

While the foundations for these companies may have been laid in cities like Boston, New York and San Francisco, the startups that are driving this next industrial revolution hail from more unlikely hubs of technology innovation in the smaller urban centers of the Sun Belt and the Southeast.

These include cities like Lexington, Ky., in states whose economies were ravaged by the 2008 financial crisis and see redemption in the entrepreneurial energy of startup businesses.

New industrial processes, such as on-demand machining and additive three-dimensional printing, may have a tremendous effect on the U.S. economy. Roughly 33 percent of the economy is fueled by manufacturing and it’s one of the arenas that has been most resistant to incursions from the technology world. Now, all of that is changing for several well-documented reasons.

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